Rosa MD, Malaguarnera M, Nicoletti F, Malaguarnera L. report of a meeting of the WHO Expert Committee on the Control of Leishmaniases, Geneva, 22–26 March 2010(949):xii–xiii, 1–186, back cover. Cutaneous Leishmaniasis in Saudi Arabia: A Comprehensive Overview.
Abdoon AM, Aldahan MA, Alzahrani AG, Alhakeem RF, Asiri AM, Alzahrani MH, Memish ZA. Cutaneous leishmaniasis in India: clinical experience with Itraconazole (R51211 Janssen). Clinco-Epidemiologic Study of Cutaneous Leishmaniasis in Bikaner, Rajasthan, India. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Īara N, Khandelwal K, Bumb RA, Mehta RD, Ghiya BC, Jakhar R, Dodd C,Salotra P, Satoskar AR. Correction of vitamin D levels may aid in CL management.Ĭopyright: © 2023 Salem et al. A significant negative correlation was found between the parasite load and 25-OH vitamin D levels (r2 = -0.53, p< 0.001).Īccording to these findings, vitamin D levels and "ApaI" VDR gene polymorphisms could affect the parasite load and susceptibility to infection, whereas BsmI, FokI, and TaqI polymorphisms did not. The "Aa" genotype in ApaI SNP of VDR had considerably lower levels of vitamin D with higher parasite load compared to the "AA" and: aa" genotypes (p = 0.02,0.02 respectively). When compared to controls, CL cases had a considerably greater frequency of the "B-A-T-F" haplotype (p = 0.04), and a significantly lower frequency of the "B-a-T-F" haplotype (p = 0.01) suggesting that these haplotypes may have the potential susceptibility or protection against CL respectively. The mean serum level of 25-OH vitamin D in CL patients who were not receiving vitamin D therapy was significantly lower compared to CL patients on vitamin D therapy and controls (p 0.05).
#VITAMIN D DEFICIENCY PARASITE INFECTION SKIN#
The skin biopsy quantified the parasite load based on the Ridley parasitic index. Serum levels of 25-OH vitamin D were assessed using the ELISA method in all participants. VDR genotyping was determined by restriction fragment length polymorphism analysis. Diphyllobothriasis represents an intestinal parasitic zoonotic infection caused by the cestode Diphyllobothrium. This is the first work conducted to assess the relationship between vitamin D status, polymorphisms of the VDR gene (BsmI, ApaI, TaqI, and FokI), and VDR haplotype with parasite tissue load and susceptibility to CL.įifty-two patients with confirmed CL (21 patients receiving vitamin D medication and 31 patients not receiving it) and 46 control subjects participated in this cross-sectional investigation. A remarkable lack of data exists in humans about the contribution of vitamin D and polymorphisms of the VDR gene in protozoan infections, especially cutaneous leishmaniasis (CL). Vitamin D and its receptor (VDR) are key modulators of the immune response where the VDR is expressed. CL endemicity was reported worldwide including in Saudi Arabia, imposing a major challenge on the health authorities.
0 kommentar(er)
